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Years later, a ruler declares one of those copies the definitive manuscript, and a rush is on to make many copies of that version — so whatever changes from the original are in this presumed important copy become widely disseminated.Scientists attempt to date genetic changes by tracing back to such spread, using a statistical model that assumes genes have a certain mutation rate over time.That the genetic changes have anything to do with brain size or intelligence "is totally unproven and potentially dangerous territory to get into with such sketchy data," stressed Dr.Francis Collins, director of the National Human Genome Research Institute.

Lahn's own calculations acknowledge that the microcephalin variant could have arisen anywhere from 14,000 to 60,000 years ago, and that the uncertainty about the ASPM variant ranged from 500 to 14,000 years ago."The genetic evolution of humans in the very recent past might in some ways be linked to the cultural evolution," he said.Other scientists urge great caution in interpreting the research."A different way to look at is it's almost impossible for evolution not to happen." Still, the findings also are controversial, because it's far from clear what effect the genetic changes had or if they arose when Lahn's "molecular clock" suggests — at roughly the same time period as some cultural achievements, including written language and the development of cities.Lahn and colleagues examined two genes, named microcephalin and ASPM, that are connected to brain size.

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