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Michael’s Hospital, Department of Surgery, University of Toronto, Ontario, Canada (N. One aneurysm was treated by trapping, allowing the excision of 2 larger samples, one of which was taken from the neck of the aneurysm (R3 and R7). H.); Institute for Physiological Chemistry and Pathobiochemistry, Westfalian Wilhelms University, Münster, Germany (R. B.); Center for Accelerator Mass Spectrometry, Livermore, CA (B. Michael’s Hospital, Labatt Family Centre of Excellence in Brain Injury and Trauma Research, Keenan Research Centre of the Li Ka Shing Knowledge Institute of St. Between September 2009 and November 2011, 10 aneurysm domes (7 ruptured, 3 unruptured, mean aneurysm size 13±10 mm) were excised from 9 patients (mean age 63±12 years) who underwent surgical clipping.C levels underlines assumptions on development of ruptured aneurysms.
C levels correlated with patient age and aneurysm size in patients with ruptured aneurysms. From the Department of Neurosurgery, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany (N. Aneurysmal collagen was isolated and purified after pepsin digestion. F Conclusions—Our preliminary data suggest that collagen extracted from intracranial aneurysms generally has a high turnover, associated with aneurysm size and patient age. Michael’s Hospital, Department of Surgery, University of Toronto, Ontario, Canada (N. Methods—Aneurysmal domes from patients undergoing surgical treatment for ruptured or unruptured aneurysms were excised. From the Department of Neurosurgery, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany (N. Purified collagen samples were transferred to quartz combustion tubes and lyophilized. Michael’s Hospital, Department of Surgery, University of Toronto, Ontario, Canada (N. C accelerator mass spectrometry analyses were performed blinded to the age of individual patients and rupture status of the aneurysm.